2010-07-31-世界卫生组织-Compiler_s_Guide_184页_635kb

International Chemical Safety Card (ICSC) Compiler's Guide Summary

Core Content Overview

The International Chemical Safety Card (ICSC) Compiler's Guide provides detailed instructions for compiling and updating ICSC cards, which are used to convey chemical safety information. The guide is updated regularly and outlines specific formatting, data entry, and revision rules for consistency and accuracy.

Main Sections and Key Information

1. History (10000000)

• Authors: Lists the primary institution responsible for the card and, if it's an update, the previous version's institution.
• Second Reviewer: Indicates the institution that reviewed the draft.
• Date of Review by Scientific Editor: Records the scientific editor's review date.
• Date of Peer-Review: Indicates the date of peer review.
• This section is used to document the evolution and updates of the ICSC card.

2. Identification (11000000)

• Chemical Name (11101000):
  • Prioritize the manufacturing industry's name.
  • Use IUPAC name if no common name exists.
  • Include synonyms and trade forms.
• Formula (11501000):
  • Provide the chemical formula, preferably in linear form for organic substances.
• CAS Number (11701000):
  • Unique Chemical Abstracts Service number for substance identification.
• RTECS Number (11703000):
  • Reference number from the Registry of Toxic Effects of Chemical Substances.
• ICSC Number (11901000):
  • Unique ICSC identifier.
• UN Number (11911000):
  • Used for transport identification.
  • Includes UN Hazard Class, Subsidiary Risks, and Pack Group.
  • Note: Use of UN number for classes or groups must be discussed by the Peer Review group.

3. Physical Properties (12000000)

• Boiling Point (12101000):
  • Indicates boiling point or range at normal atmospheric pressure (101.3 kPa).
  • Use 12102 if a different pressure is specified.
• Sublimation Point (12104000):
  • Applies to substances that sublime (solid to vapor without melting).
• Decomposition Temperature (12106/12111):
  • Replaced "Boiling point (decomposes)" with "Decomposes at [°C]" to avoid confusion.
• Melting Point (12113000):
  • Indicates melting point or range at normal atmospheric pressure.
• Relative Density (12301000):
  • Compares substance to water (1 = water).
  • For gases, indicates liquid phase density.
  • For substances with critical temperature < -10°C, skip this phrase.
• Density (12302000):
  • Units: g/cm³, g/l, or kg/m³.
  • Rounding rules vary based on the value.
• Solubility in Water (12304/12310000):
  • Preferred unit: g/100ml at 20°C.
  • Qualitative descriptions: very poor, poor, moderate, good, very good.
  • Use 'reaction' if substance reacts with water.
  • For gases, use solubility under 1 atm pressure.
• Vapour Pressure (12501000/12504000):
  • Units: kPa or Pa, depending on the magnitude.
  • Rounding rules apply based on the value.
  • Skip for substances with boiling point ≥ 350°C.
• Relative Vapour Density (12507000):
  • Compares gas/vapour to air.
  • Applies only to vapour from boiling liquids.
• Viscosity (1260000/12601000):
  • Kinematic viscosity at 40°C in mm²/s.
  • Conversion to dynamic viscosity and density is provided.
  • Low viscosity indicates higher aspiration risk.
  • GHS categories for aspiration hazard are noted (Category 1 and 2).

Main Views and Key Concepts

• Consistency in Naming and Identification: Emphasizes using standardized chemical names, including IUPAC, synonyms, and trade names.
• Precision in Physical Properties: Provides specific rounding rules for density, boiling point, and vapour pressure to ensure accurate and comparable data.
• Toxicological and Safety Relevance: Highlights the importance of including data on aspiration hazards, decomposition temperatures, and solubility.
• Revisions and Peer Review: Notes that changes to the ICSC format must be approved by the Peer Review group and documented in the History section.
• GHS Integration: Mentions the integration of GHS (Globally Harmonized System) categories for certain hazards like aspiration.

Key Information for Compilation

• Data Sources: Use of CAS, RTECS, and EC/EINECS numbers for accurate identification.
• Units and Rounding: Detailed instructions on units and rounding for each property to maintain data integrity.
• Special Cases:
  • Gases with critical temperature < -10°C do not have a liquid phase.
  • Substances with boiling point ≥ 350°C are not mentioned for vapour pressure.
  • For solubility, qualitative terms are used alongside numerical values when applicable.
• Notes Section: Used to clarify or provide additional information when specific data is not available or when special conditions apply.

Conclusion

The ICSC Compiler's Guide ensures that safety cards are standardized, accurate, and informative. It provides detailed instructions for compiling data on chemical names, physical properties, and safety-related characteristics. Emphasis is placed on proper terminology, rounding rules, and the inclusion of relevant safety classifications (GHS), while also noting the importance of peer review and revision processes.